The Effect of Low Dose of Aspirin on the Preeclampsia in Pregnant Women: A Meta-Analysis


  • Meike Arianty Master's Program in Public Health, Universitas Sebelas Maret
  • Bhisma Murti Master's Program in Public Health, Universitas Sebelas Maret
  • Uki Retno Budihastuti Department of Obstetrics and Gynecology, Dr. Moewardi Hospital



Background: In 2020 there were 4,627 maternal deaths in Indonesia. Preeclampsia is a complica­tion in pregnancy that occurs 2-8% of all pregnancies and is a major cause of maternal morbidity. Low-dose aspirin has been shown to be a safe and effective primary prevention for the incidence of preeclampsia. With preventive measures can reduce both moral and material losses for patients at high risk for the incidence of preeclampsia. The purpose of this study was to estimate the magnitude of the effect of low-dose aspirin on the incidence of preeclampsia in pregnant women based on previous research.

Subjects and Method: This study is a systematic review and meta-analysis. Article searches were conducted using electronic databases such as Google Scholar, PubMed, Cochrane, Science Direct. The articles used are published articles from 2012-2022. The keywords used to search the article were “Aspirin OR Acetylsalicylic Acid AND Prevention AND Pre-Eclampsia OR Toxemia AND Randomized Controlled Trials”. The inclusion criteria used are articles with randomized control trial studies, full text articles are available, the results of the analysis used are Risk Ratio. The population of the study was high-risk pregnant women, the research intervention was the administration of low-dose aspirin, the study comparison was a placebo, and the outcome of the study was preeclampsia, the articles were in English or Indonesian. The article search results are listed in the PRISMA diagram and analyzed using the Review Manager 5.3 application.

Results: A total of 7 articles from China, America, India, Congo, Guatemala, Pakistan, and Finland showed that aspirin had an effect of 0.87 times in reducing the incidence of preeclampsia when compared with placebo or no administration (RR = 0.87; 95% CI 0.72 to 1.05). although not statistically significant (p=0.160).

Conclusion: Low-dose aspirin affects the incidence of preeclampsia in pregnant women.


low-dose aspirin, preeclampsia, pregnant women


Abramovici A, Jauk V, Wetta L, Cantu J, Edwards R, Biggio J, Tita A (2015). Low-dose aspirin, smoking status, and the risk of spontaneous preterm birth. Am J Perinatol : 32(5):445-50. DOI: 10.1055/s-0034-1390352.

Amin O, Tasnim N, Naeem S (2020). Prevention of pre-eclampsia with low dose aspirin in primigravida. MOJ Women

CASP (2021). Critical appraisal skills programme randomized control study checklist. diakses pada 11 Januari 2022

Duley L, Meher S, Hunter KE, Seidler AL, Askie LM. (2018). Antiplatet agents for preventing pre-eclamsia and its complications.CochraneDatabase SystRev. Issue 10 Art No: CD004659. DOI 10.1002/14651858. CD004659.pub3

Espinoza J (2021). Low-dose aspirin fro the prevention of preeclamsia. JAMA 326 (12).1153-1155. 2021.14646

Ferri FF (2022). Ferri

Gu W, Lin J, Hou YY, Lin N, Song MF, Zeng WJ, Shang J, Huang HF (2017). Effects of low-dose aspirin on the prevention of preeclampsia and pregnancy outcomes: A randomized controlled trial from Shanghai, China. Eur J Obstet Gynecol Reprod Biol. 248:156-163. DOI: 10.1016/j.ejogrb.2020.03.038.

Hoffman MK et al (2020). Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial. Lancet 395 (10220): 285-293. DOI: 10.1016/S01406736-(19)32973-3.

Iskandar F, Limiardi SP, Fransisca A (2017). Aspirin dosis rendah untuk pencegahan preeklamsia dan komplikasinya (Low dose aspirin for prevention of preeclampsia and its complications). CDK, 44(5) 362-365

Kemenkes (2021). Profil kesehatan Indonesia tahun 2020 (Indonesia's health profile 2020). Kementerian Kesehatan Republik Indonesia. Accessed November 2021.

Lin L, Huai J, Li B, Zhu Y, Juan J, Zhang M, Cui S, et al (2021). A randomized controlled trial of low-dose aspirin for the prevention of preeclampsia in women at high risk in China. Am J Obstet Gynecol. 226(2): 251.e1-251.-e12. doi: 10.1016/j.ajog.2021.08.004.

Odibo AO, Goetzinger KR, Odibo L, Tuuli MG (2015). Early prediction and aspirin for prevention of pre-eclampsia (EPAPP) study: a randomized controlled trial. Ultrasound Obstet Gynecol. 46(4):414-8. doi: 10.1002-/uog.14889.

Scazzocchio E, Oros D, Diaz D, Ramirez JC, Ricart M, Meler E, Gonzales et al (2017). Impact of aspirin on trophoblastic invasion in women with abnormal uterine artery doppler at 11-14 weeks: a randomized controlled study. Ultrasound Obstet Gynecol, 49(4): 435-441.

Tolcher MC, Sangi-Haghpeykar H, Mendez-Figueroa H, Aagaard KM (2020). Low-dose aspirin for preeclampsia prevention: efficacy by ethnicity and race. Am J Obstet Gynecol. 2(4): 100184. DOI: 10.1016/j.ajogmf.20-20.100184.

Xu TT, Zhao Fun, et al (2015). Low-dose aspirin for preventing preeclampsia and its complications: A meta-analysis. J Clin Hypertens. 17 (7). 567-573.

Villa PM, Kajantie E, R

WHO (2011a). Evidance table-guideline prevention and treatment of pre-eclampsia and eclampsia. accessed November 2021.

WHO (2011b). WHO recomendation for prevention and treatment of preeclampsia and eclampsia. accessed November 2021.




How to Cite

Arianty, M., Murti, B., & Budihastuti, U. R. (2022). The Effect of Low Dose of Aspirin on the Preeclampsia in Pregnant Women: A Meta-Analysis. Journal of Maternal and Child Health, 7(2), 193–202.