Oral and Injection Hormonal Contraceptives Uptake and Their Risk to Breast Cancer: A Meta-Analysis


  • Dian Asih Ning Utami Master's Program in Public Health, Universitas Sebelas Maret
  • Bhisma Murti Master's Program in Public Health, Universitas Sebelas Maret
  • Uki Retno Budihastuti Department of Obstetrics and Gynecology, Dr. Moewardi Hospital/Faculty of Medicine, Universitas Sebelas Maret




Background: Breast cancer cases are the biggest contributor to death in women in the world. One of the risk factors is injectable hormonal contraceptives and pills. Injectable hormonal contraceptives and pills contain synthetic hormones progesterone and estrogen that trigger breast cancer, due to an increase in the content of these hormones in the body, this results in an opportunity to experience uncontrolled cell division resulting in gene mutations in the breast gland. The purpose of this study was to analyze the effect of the use of injectable and pill hormonal contraceptives on the incidence of breast cancer using a meta-analysis study.

Subjects and Method: This research is a systematic review and meta-analysis using PRISMA flowchart diagram guidelines. The article search process was carried out between 2015-2022 using databases including Google Scholar, PubMed, Science Direct and Springerlink. The keywords used in the database search were


injectable hormonal contraception, pill hormonal contraception, breast cancer


Alsolami FJ, Azzeh FS, Ghafouri KJ, Ghaith MM, Almaimani RA, Almasmoum HA, Abdulal R, et al. (2019). Determinants of breast cancer in saudi women from Makkah region: a case control study (breast cancer risk factors among Saudi Arabia women). BMC Public Health. 19(1): 4–11: https://doi.org/ 10.1186/s1288901979423.

Amadou A, Alban F, Gabriela TM, Carolina OO, Angelica AL, Fiona M, Carine B, et al. (2013). Hormonal therapy and risk of breast cancer in Mexican women. PLoS ONE, 8(11). DOI: 10.1371/journal.pone.0079695.

Baziad A (2014). Kontrasepsi hormonal edisi kedua (Hormonal contraception second edition). Jakarta: PT Bina Pustaka Sarwono Prawirohardjo.

BKKBN. 2015. Keluarga berencana dan kontrasepsi (Family planning and contraception). Cetakan ke 5. Jakarta: Pustaka Sinar Harapan.

Cherif M, Serraino D, Bouaoud S, Boudaoud K, Atoui S, Merghem I, Toffolutti F, et al. (2020). sociodemographic and reproductive risk factors for breast cancer: a case control study in the setif province, Algeria. Asian Pac J Cancer Prev. 21(2): 457–464. https://doi.org/10.31557/APJCP.2020.21.2.457.

Christopher IL, Elisabeth FB, Peggy LP, Daling JR (2012). Effect of depomedroxyprogesterone acetate on breast cancer risk among women 20 to 44 years of age. Cancer Res J. 72(8): 2028–2035. DOI: 10.1158/00085472.CAN114064.

El Sharif N, Khatib I (2021). Reproductive factors and breast cancer risk in Palestine: a case control study. Cancer Epidemiol, 74(07). https://doi.org/10.1016/j.canep.2021. 102019.

Global Burden Cancer (2020). Indonesia-global cancer observatory. WHO International Agency for Research on Cancer.

Gray DJP, Sidaway LK, White E, Thorne A, Evans PH (2018). Continuity of care with doctors a matter of life and death? a systematic review of continuity of care and mortality. BMJ Open, 8(6). https://doi.org/10.1136/BMJOPEN2017021161.

Kementerian Kesehatan RI (2015). Panduan penatalaksanaan kanker payudara (Breast cancer management guide).

Kementerian Kesehatan RI (2020). Profil kesehatan Indonesia) Indonesian health profile) Kementerian Kesehatan Republik Indonesia.

Mikolajewicz N, Komarova SV (2019b). Meta-analytic methodology for basic research: a practical guide. Frontiers in Physiology. 1(03): 203. https://doi.org/10.3389/FPHYS.2019.00203.

Moradinazar M, Marzbani B, Shahebrahimi K, Shahabadi S, Marzbani B (2019). Hormone therapy and factors affecting fertility of women under 50-year-old with breast cancer. Breast Cancer (Dove Med Press), 11: 309–319. https://doi.org/10.2147/BCTT.S218394.

Murti B (2018). Prinsip Dan Metode Riset Epidemiologi Edisi V (Principles and Methods of Epidemiological Research Edition V). Surakarta: Program Studi Ilmu Kesehatan Masyarakat.

Paul ENJ, Henri E, Sara SND, Emile MT. (2020). Risk factors for breast cancer in the city of Douala: a case control study. advances in breast cancer research, 09(03): 66–77. https://doi.org/10.4236/abcr.2020.93006.

Rahma S, Mursyidah A, Rauf YY. (2019). Kadar gula darah pengguna kontrasepsi hormonal (Blood sugar levels of hormonal contraceptive users). Jam Nurs J. 1(2): 73–84. DOI: 10.37311/jnj.v1i2.2501.

Vinogradova Y, Coupland C, Hippisley CJ. (2020). Use of hormone replacement therapy and risk of breast cancer: nested case-control studies using the research and cprd databases. The BMJ, 371. https://doi.org/10.1136/bmj.m3873.

Yuan X, Fang Y, Can H, Hui L, Xiaorong Z, Ping T, Hui L, Zhuping X, Jiayuan L (2019). Induced abortion, birth control methods, and breast cancer risk: a case-control study in China. J Epidemiol. 29(5): 173–179. https://doi.org/10.1093/aje/155.5.478.




How to Cite

Utami, D. A. N., Murti, B., & Budihastuti, U. R. (2022). Oral and Injection Hormonal Contraceptives Uptake and Their Risk to Breast Cancer: A Meta-Analysis. Journal of Maternal and Child Health, 7(3), 346–358. https://doi.org/10.26911/thejmch.2022.07.03.11