Pathological Changes of Placenta in Intrauterine Fetal Death


  • Sanchita Paul Jorhat Medical College and Hospital
  • Abhijit Kalita Jorhat Medical College and Hospital



Background: Examination of placenta is one of the most common investigations undertaken after a stillbirth and  is one of the most valuable. Examination of placenta can yield information that may be important in the immediate and later management of the mother and infant. The present study aims to evaluate the pathological changes in placenta in intrauterine fetal deaths.

Subjects and Method: It is a cross sectional comparative study conducted in Jorhat Medical College and Hospital, Jorhat for a period of one year from July 2020 to June 2021. Total 144 placenta were collected that comprised of 72 cases of intra uterine fetal death and 72 controls were taken. The cases and controls were selected by systematic random sampling. Statistical correlation was carried out by using Student T test with SPSS software or statistical significance p value of less than 0.05 was considered.

Results: Placental weight, diameter and umbilical cord length and diameter were found to be significantly decreased in fetal deaths (p <0.05). Intervillous fibrinoid, peri villous fibrinoid, calcification, syncytial knots, infarction were found to be significantly associated with intrauterine fetal deaths in this study (p <0.05).

Conclusion: The present study shows that significant information can be gathered by placental examination in adverse fetal outcome and can be used to know the cause of death and further management and prevention in future.

Keywords: intrauterine death, syncytial knots, calcification, intervillous fibrin, peri villous fibrin

Correspondence: Sanchita Paul, house no. 129, Karimganj, Assam. Pin: 788710. Phone: 9678801472. Email:

Author Biographies

Sanchita Paul, Jorhat Medical College and Hospital

Medical officer

Abhijit Kalita, Jorhat Medical College and Hospital

Medical officer


Arch. Patho Lab Med (2008): 641-651

Chibber R (2005). Unexplained antepartum fetal deaths: what are the determinants? Arch Gynecol Obstet. 271(4):286-91. doi: 10.1007/s0040400406061. Epub 2004 May 7. PMID: 15133693.

Confidential Enquiry into maternal and child health: Perinatal mortality 2008: England, Wales and Northern Ireland. London: Centre for Enquiries into Maternal and Child Health 2010.

Frøen JF, Arnestad M, Vege A, Irgens LM, Rognum TO, Saugstad OD, Stray-Pedersen B (2002). Comparative epidemiology of sudden infant death syndrome and sudden intrauterine unexplained death. Arch Dis Child Fetal Neonatal Ed. 87(2):F118-21. doi: 10.1136/fn.87.2.f118.

Georgiadis L, Keski-Nisula L, Harju M, Räisänen S, Georgiadis S, Hannila ML, Heinonen S (2014). Umbilical cord length in singleton gestations: a Finnish population-based retrospective register study. Placenta. 35(4): 275-80. doi: 10.1016/j.placenta.2014.02.001.

Heazell AE, Byrd LM, Cockerill R, Whitworth MK (2011). Investigations following stillbirth which tests are most valuable? Arch Dis Child. 96(1). doi: 10.1136/archdischild.2011.300157.41

Huang DY, Usher RH, Kramer MS, Yang H, Morin L, Fretts RC (2000). Determiants of unexplained antepartum fetal deaths. Obstet Gynecol. 95(2):215-21. doi: 10.1016/ s00297844(99)00536-0.

Kishwara S, Ara S, Rayhan KA, Begum M (2009). Morphological Changes of Placenta in Preeclampsia. Bangladesh Journal of Anatomy. 7(1):49–54. https://doi. org/10.3329/bja.v7i1.3026

Miwa I, Sase M, Torii M, Sanai H, Naka-mura Y, Ueda K (2014). A thick pla-centa: a predictor of adverse pregnancy outcomes. Springerplus. 3:353. doi: 10.1186/219318013353.

Korteweg FJ, Erwich JJHM, Holm JP, Ravisé JM, van der Meer J, Veeger NJGM, Timmer A (2009). Diverse placental pathologies as the main causes of fetal death. Obstet Gynecol. 114(4):809-817. doi: 10.1097/AOG.0b013e3181b 72ebe. PMID: 19888039.

Schmid A, Jacquemyn Y, Loor JD (2013). Intrauterine growth restriction associated with excessively long umbilical cord. Clin Pract. 3(2):e23. doi: 10.40-81/cp.2013.e23.

Shaaban LA, Al-Saleh RA, Alwafi BM, Al-Raddadi RM (2006). Associated risk factors with ante-partum intrauterine fetal death. Saudi Med J. 27(1):76-9. PMID: 16432598.

Stanton C, Lawn JE, Rahman H, Wilczynska-Ketende K, Hill K. Stillbirth rates: delivering estimates in 190 countries. Lancet. 2006 May 6;367(9521):1487-94. doi: 10.1016/S0140 6736(06)685863. PMID: 16679161

Szymanowski K, Chmaj-Wierzchowska K, Florek E, Opala T (2007). Złogi wapnia w łozyskuczy świadcza wyłacznie o paleniu papierosów? [Do calcification of placenta reveal only maternal cigarette smoking?]. Przegl Lek. 2007;64(10):879-81. Polish.

Tamrakar SR, Chawla CD (2012). Intrauterine foetal death and its probable causes: two years experience in Dhu-likhel Hospital-Kathmandu University Hospital. Kathmandu Univ Med J (KUMJ). 10(40):44-8. doi: 10.3126/kumj.v10i4. 10994.




How to Cite

Paul, S., & Kalita, A. (2023). Pathological Changes of Placenta in Intrauterine Fetal Death. Journal of Maternal and Child Health, 8(3), 356–362.