Advanced Maternal Age and Low Birth Weight in Primigravid Births


  • Kezia Adelize Aurelia Junus Atma Jaya Catholic University of Indonesia
  • Ana Lucia Ekowati Atma Jaya Catholic University of Indonesia
  • Bertha Soegiarto Atma Jaya Catholic University of Indonesia
  • Andy Setiawan Atma Jaya Catholic University of Indonesia



Background: The number of women who delay pregnancy is increasing. Advanced Maternal Age/ AMA (pregnancies in women aged 35 years or older) have increased risks of complications, such as low birth weight/LBW (up to 1.59 times). The aim of this study is to know the association between AMA with LBW in primigravid births.
Subjects and Method: This descriptive and analytical, cross sectional research consists of 169 primigravid births in Atma Jaya Hospital Jakarta, collected with a total sampling method for births between February 2016 to September 2021 meeting inclusion criteria. Independent variable included primigravid maternal age and dependent variable included birth weight. Prematurity was used as a dependent variable and an independent variable in two separate analyses. Characteristics of data are described, and analyses were done with the Fisher’s exact test for the associations between primigravid AMA and LBW, , between primigravid AMA and prematurity, and between primigravid prematurity and LBW Spearman’s correlation test was done for the correlation between primigravid maternal age and birth weight.
Results: The proportions of women with higher education and maternal diseases are more elevated in AMA. LBW prevalence is 14.79%. The proportion of LBW is higher in AMA (OR=2.045; CI 95% 0.513 to 8.147), with statistically insignificant association (p=0.253). The correlation between maternal age and birth weight is insignificant (p=0.113). AMA has insignificantly higher odds for prematurity (OR=1.139; CI 95% 0.234 to 5.538; p=0.567). The association between prematurity and LBW is highly significant (OR 49.224; CI 95% 15.470 to 156.621; p<0.001).).
Conclusion: Primigravid women aged ≥35 years have higher proportions of maternal diseases. Despite being statistically insignificant, AMA has higher odds for LBW. Prematurity is highly asso¬ciated with LBW. Further research concerning high-risk maternal age needs to be done to improve women’s and children’s health.

Keywords: advanced maternal age, primigravida, low birth weight.

Ana Lucia Ekowati. Department Of Medical Biology, School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia. Jl. Pluit Selatan Raya No.19, Jakarta, 14440. Email:


Aassve A, Cavalli N, Mencarini L, Plach S, Sanders S (2021). Early assessment of the relationship between the COVID-19 pandemic and births in high-inco-me countries. Proc Natl Acad Sci USA. 118(36):e2105709118. 1073/pnas.2105709118.

Cunningham FG (2018a). Preconceptional Care, in: Williams Obstetrics. McGraw-Hill, New York.

Cunningham FG (2018b). Prenatal Care, in: Williams Obstetrics. McGraw-Hill, New York.

Cutland CL, Lackritz EM, Mallett-Moore T, Bardají A, Chandrasekaran R, Lahari-ya C, Nisar MI, et al. (2017). Low birth weight: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine. 35: 6492–6500. doi: 10.1016/j.vaccine. 2017.01.049.

Fuchs F, Monet B, Ducruet T, Chaillet N, Audibert F (2018). Effect of maternal age on the risk of preterm birth: A large cohort study. PLoS One. 13: e019-1002. doi: 10.1371/journal.pone.0191002.

Goisis A, Remes H, Barclay K, Martikainen P, Myrskylä M (2017). Advanced ma-ternal age and the risk of low birth weight and preterm delivery: a within-family analysis using finnish population registers. Am J Epidemiol. 186: 1219–1226. doi: 10.1093/aje/kwx177

Indonesia Demographic and Health Survey Report (2017, 2018). Central Bureau of Statistics, National Population and Family Planning Board, Ministry of Health, USAID (BPS, BKKBN, Kemenkes, USAID).

Indonesia Women’s Profile 2013 (2013). Ministry of Women’s Empowerment and Child Protection (Kementerian Pemberdayaan Perempuan dan Perlindungan Anak), Jakarta.

Indonesia Women’s Profile 2019, (2019) Ministry of Women’s Empowerment and Child Protection (Kementerian Pemberdayaan Perempuan dan Perlindungan Anak), Jakarta.

Inoue S, Naruse H, Yorifuji T, Kato T, Murakoshi T, Doi H, Subramanian S (2016). Association between short maternal height and low birth weight: a hospital-based study in Japan. J Korean Med Sci. 31: 353. doi: 10.33-46/jkms.2016.31.3.353

Kahveci B, Melekoglu R, Evruke IC, Cetin C (2018). The effect of advanced maternal age on perinatal outcomes in nulliparous singleton pregnancies. BMC Pregnancy Childbirth. 18: 343. doi: 10.1186/s12884-018-1984-x

Kaur S, Ng CM, Badon SE, Jalil RA, Maykanathan D, Yim HS, Jan Mohamed HJ (2019). Risk factors for low birth weight among rural and urban Malaysian women. BMC Public Health. 19: 539. doi: 10.1186/s12889-019-6864-4

Kim HE, Song IG, Chung SH, Choi YS, Bae CW (2019). Trends in birth weight and the incidence of low birth weight and advanced maternal age in Korea between 1993 and 2016. J Korean Med Sci. 34(4): e34.

Kliegman RM (2020). High-Risk Pregnancies, in: Suhrie KR, Tabbah SH (Eds.), Nelson textbook of pediatrics. Elsevier, Philadelphia, MO.

Laopaiboon M, Lumbiganon P, Intarut N, Mori R, Ganchimeg T, Vogel J, Souza J, et al. (2014). Advanced maternal age and pregnancy outcomes: a multi-country assessment. BJOG. 121: 49–56. doi: 10.1111/1471-0528.12659

Lean SC, Derricott H, Jones RL, Heazell AEP (2017). Advanced maternal age and adverse pregnancy outcomes: A systematic review and meta-analysis. PLoS One. 12: e0186287. doi: 10.1371/journal.pone.0186287

Lei F, Zhang L, Shen Y, Zhao Y, Kang Y, Qu P, Mi B, et al. (2020). Association between parity and macrosomia in Shaanxi Province of Northwest China. Ital J Pediatr 46, 24. doi: 10.1186/s13052-020-0784-x

National Baseline Health Research “RIS-KESDAS” Report 2018 (2019) Ministry of Health, Bureau of Research and Health Development, Jakarta.

Oktaviani ET (2017). Hubungan usia, paritas dan kehamilan ganda dengan kejadian BBLR di RSUD Abdoel Moe-loek Provinsi Lampung Tahun 2016 (The relationship between age, parity and multiple pregnancies with the in-cidence of LBW at Abdoel Moeloek Hospital in Lampung Province in 2016). Jurnal Kesehatan Wira Buana 1: 7–7.

Pinheiro RL, Areia AL, Mota Pinto A, Donato H (2019). Advanced maternal age: adverse outcomes of pregnancy, a meta-analysis. Acta Med Port. 32: 219–226. doi: 10.20344/amp.11057

Rahfiludin MZ, Dharmawan Y (2018). Risk factors associated with low birth weight. Kesmas: National Public Health Journal 13. doi: 10.21109/kesmas.v13i2.1719.

Tazkiah M, Wahyuni CU, Martini S (2013). Determinan epidemiologi kejadian BBLR pada daerah endemis malaria di Kabupaten Banjar Provinsi Kalimantan Selatan (Epidemiological determinants of LBW incidence in malaria endemic areas in Banjar District, South Kalimantan Province). Jurnal Berkala Epidemiologi. 1: 266–276.

World Health Organization (2014). WHO Global Nutrition Targets 2025: Low birth weight policy brief. 25_policybrief_lbw/en/

Zhang G, Bacelis J, Lengyel C, Teramo K, Hallman M, Helgeland Ø, Johansson S, et al. (2015). Assessing the causal relationship of maternal height on birth size and gestational age at birth: a mendelian randomization analysis. PLoS Med. 12: e1001865. doi: 10.1371/journal.pmed.1001865.




How to Cite

Junus, K. A. A., Ekowati, A. L., Soegiarto, B., & Setiawan, A. (2023). Advanced Maternal Age and Low Birth Weight in Primigravid Births. Journal of Maternal and Child Health, 8(5), 613–624.